WG4 was tasked with assessing the use of molecular markers in conjunction with morphology in the assessment of specimens from the lower anogenital tract. In doing so, over 2000 articles were identified from the literature search. Using pre-specified criteria and following a systematic title/abstract and full text review process, this number was culled to 50 from which complete data extraction was performed. The vast majority of the articles dealt with cervical disease, however some articles did address disease of vulvar/penile and anal sites. Of the selected literature, prospective studies and those having histologic adjudication as a gold standard were given more weight. A formal and more rigorous evidence grading process is currently in progress, and will be finalized prior to the March 2012 conference.
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WG4 References
Literature Review Flow Diagram
Scope/Overall Purpose and Key Questions