Education & eLearning
Immune Response to HPV and Management of Genital Warts

    Presented by Dr. J. Thomas Cox, MD

Release Date of Activity: November 2009
Expiration Date of Activity for AMA PRA Credit: November 30, 2012
Estimated Time to Complete This Activity: 1 hour


Authors and Reviewers Biosketches
To register for the Online CME Series click here

Course Summary and Competency Goals
Most obstetrician-gynecologists and family practitioners, as well as many dermatologists and advanced practice clinicians, treat genital human papillomavirus (HPV) lesions. However, few understand the critical role that the immune system plays in treatment outcomes. An increased understanding of the role of immunity in the successful clearance of these lesions should improve clinical management of genital warts and cervical, vaginal, vulvar, penile, and anal intraepithelial neoplasia. An important aspect of successful management of men and women with genital HPV is the ability to provide education and counseling about this virus. Optimal support of patient requires full understanding of the biology, epidemiology and natural history of HPV, and of the role of the host immune response in clearing HPV lesions. A better understanding of these issues should improve communication skills with patients, colleagues, and the public about HPV and improve decision-making in the choice of options in the treatment of HPV-induced lesions, as well as provide clinicians with a better understanding of the costs to society, and to the individual, of HPV infections. The 2006 Centers for Disease Control and Prevention (CDC) guidelines for the treatment of genital warts will be discussed within the framework of this improved understanding of the role of immunity in clearing these lesions and the sensitivity to the special needs of patients who have HPV.

This evidence-based online activity was specifically designed to improve patient care, medical knowledge, practice-based learning, and systems-based practice gaps.


Learning Objectives
Upon completion of the learning activity and its post-test, participants should be able to:
  • Apply an improved understanding of the natural history of HPV and the host immune response to optimal practice, particularly as it relates to success or failure in the treatment of lower genital tract HPV disease;
  • Determine the best treatment option, or the best combination of options, for men and women with genital warts;
  • Utilize newer options for the treatment of genital warts such as immune response modifiers and kunecatechins; and,
  • Discuss the 2006 CDC STD Guidelines for the treatment of genital warts.
Intended Audience
The target audience of the Online CME lecture entitled, "Immune Response to HPV and Management of Genital Warts" are those clinicians who diagnose and treat men and women with genital HPV disease and those clinicians who treat genital warts. This activity was designed to meet the CME needs of the practicing obstetrician-gynecologist, family physician, dermatologist, gynecologic oncologist, pathologist, obstetrics/gynecology or family medicine resident, nurse practitioner, certified nurse midwife, and physician's assistant.

Accreditation Statement
The American Society for Colposcopy and Cervical Pathology (ASCCP) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to sponsor continuing medical education for physicians.

Continuing Medical Education (CME) Credit
The ASCCP designates this enduring material for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Management of Conflicts of Interest and Contributed Funds
As an accredited provider of CME credit, ASCCP is required to comply with the ACCME's Standards for Commercial Support and has implemented a management process to ensure that anyone who is in a position to affect the content of the educational activity (e.g., faculty, planners, etc.) has disclosed to us all relevant financial relationships with any commercial interest and has ensured that those relationships do not influence presentation materials. All faculty have agreed to base their presentations on best available evidence. ASCCP discloses to learners any financial relationship(s) to healthcare-related commercial interests existing within the past 12 months to include the following information: 1) the name of the individual; 2) the name of the commercial interest; and, 3) the nature of the relationship the person has with each commercial interest. Slides and slide notes are reviewed for possible bias prior to the activity's release by the Accreditation Committee and peer-reviewers, and potential conflicts of interest are resolved prior to the live presentation. Any discussion of off-label use of products is noted when appropriate, as is discussion of any limitations on the information that is presented, such as data that are preliminary or that represent ongoing research, interim analyses, and/or unsupported opinion. Disclosures of these commitments and/or relationships are published in these lecture materials and provided prior to the start of the activity, so the learners may formulate their own judgments regarding the presentation(s). Under ASCCP policy, anyone declining either to disclose or amend material to eliminate potential bias identified by the Accreditation Committee will be replaced.

Author, Reviewers, and Planners' Disclosure Information

The following are all reported disclosures of interest or potential conflicts from the 12 months preceding this activity:

J. Thomas Cox, MD (Author) - serves on the Data and Safety Monitoring Board for Merck & Co and receives a fee for his service. He is also a scientific advisory board member for Gen-Probe and an advisory board member for Abbott, for both of which he receives an honorarium.
Hope K. Haefner, MD (CME Reviewer) - served on the speakers' bureau for Merck & Co and receives an honoraria. Effective March 2010 forward, she has had no financial relationships or conflicts to disclose.
Beth Colvin Huff, MSN, NP (CME Reviewer) - is a shareholder, receiving dividends with Hologic and serves on the speakers' bureaus of Merck & Co and Qiagen, for which she receives honoraria.

Those reporting no financial relationships or conflict of interest to disclose:
L. Stewart Massad, MD (Accreditation Committee Co-chair/CME Reviewer/Planner)
Herschel W. Lawson, MD (CME Reviewer/Accreditation Committee Co-chair)
Alan G. Waxman, MD (CME Reviewer)
Kathleen Poole (ASCCP Executive Director, Planner)
Carol Noonan (ASCCP Assistant Course Administrator, Planner)


CME Inquiries
For all CME certificate inquiries, please contact Ms. Carol Noonan at cnoonan@asccp.org or by mail at the ASCCP National Office, 152 West Washington Street, Hagerstown, MD 21740 or by phone at 301-733-3640.
   
 
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